Inhibition of N-myc Downstream–regulated Gene-2 Is Involved in an Astrocyte-specific Neuroprotection Induced by Sevoflurane Preconditioning
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چکیده
منابع مشابه
Sevoflurane preconditioning-induced neuroprotection is associated with Akt activation via carboxy-terminal modulator protein inhibition.
BACKGROUND Sevoflurane preconditioning has a neuroprotective effect, but the underlying mechanism is not fully understood. The aim of the present investigation was to evaluate whether sevoflurane-induced cerebral preconditioning involves inhibition of carboxy-terminal modulator protein (CTMP), an endogenous inhibitor of Akt, in a rat model of focal cerebral ischaemia. METHODS Male Sprague-Dawl...
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942 November 2012 T concept “ischemic pre conditioning” was introduced in the literature in 1986.1 It describes a phenomenon in which short episodes of ischemia before a prolonged episode of ischemia provide protection against the detri mental effects of the prolonged isch emia. Subsequently, various stimuli, in addition to short episodes of ischemia, have been shown to induce a precondition...
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Objective(s):Every year, a large number of people lose their lives due to stroke. Stroke is the second leading cause of death worldwide. Surprisingly, recent studies have shown that preconditioning with hyperoxia (HO) increases tissue tolerance to ischemia, ultimately reducing damages caused by stroke. Addressed in this study are beneficial contributions from HO preconditioning into reduced har...
متن کاملActivation of K2P channel–TREK1 mediates the neuroprotection induced by sevoflurane preconditioning
BACKGROUND Preconditioning with volatile anaesthetic agents induces tolerance to focal cerebral ischaemia, although the underlying mechanisms have not been clearly defined. The present study analyses whether TREK-1, a two-pore domain K(+) channel and target for volatile anaesthetics, plays a role in mediating neuroprotection by sevoflurane. METHODS Differentiated SH-SY5Y cells were preconditi...
متن کاملN-Myc downstream-regulated gene 2 is involved in p53-mediated apoptosis
The tumor suppressor, p53, is a transcription factor which can modulate the transcription of a number of target genes that are involved in cell-cycle arrest and apoptosis. However, the apoptotic pathway mediated by p53 is not fully understood. Here, we showed that N-Myc downstream-regulated gene 2 (NDRG2) is a new target gene that is regulated by p53. NDRG2 mRNA and protein levels can be upregu...
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ژورنال
عنوان ژورنال: Anesthesiology
سال: 2014
ISSN: 0003-3022
DOI: 10.1097/aln.0000000000000314